FITC标记的N-乙酰转移酶8样蛋白抗体
产品名称： FITC标记的N-乙酰转移酶8样蛋白抗体
英文名称： Anti-NAT8L/FITC
产品编号： HZ-11593R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NAT8L/FITC Conjugated antibody
FITC标记的N-乙酰转移酶8样蛋白抗体
| 产品编号 | bs-11593R-FITC |
| 英文名称 | Anti-NAT8L/FITC |
| 中文名称 | FITC标记的N-乙酰转移酶8样蛋白抗体 |
| 别 名 | Camello-like protein 3; CML3; Hcml3; N acetyltransferase 8 like (GCN5 related, putative); N-acetylaspartate synthetase; N-acetyltransferase 8-like protein; NAA synthetase; NAT8 like; Nat8l; NAT8L_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 发育生物学 信号转导 细胞周期蛋白 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NAT8L (201-302aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). Function: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Subcellular Location: Cytoplasm. Membrane; Single-pass membrane protein (Potential). Microsome membrane; Single-pass membrane protein (By similarity). Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. Tissue Specificity: Expressed in brain. DISEASE: Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED) [MIM:614063]. A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. Similarity: Belongs to the camello family. Contains 1 N-acetyltransferase domain. Database links: Entrez Gene: 339983 Human Entrez Gene: 269642 Mouse Omim: 610647 Human SwissProt: Q8N9F0 Human SwissProt: Q3UGX3 Mouse Unigene: 318529 Human Unigene: 274610 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码单程膜蛋白，其包含N-乙酰转移酶的GCN5或NAT超家族的保守序列，并且是N-酰基转移酶（NAT）超家族的成员。该蛋白是一种神经元特异性蛋白，是N-乙酰天门冬氨酸（NAA）生物合成酶，催化L-天冬氨酸和acetyl CoA合成NAA。NAA是神经系统特有的乙酰辅酶A的主要储存和转运形式。基因突变导致原发性NAA缺乏（亚乙酰基）。