<p style="color: #3c506c;"><strong><span style="color: #f39800;"><span style="font-family: Helvetica Neue宋体;">产品信息</span></span></strong></p> <div class="tableResponsive" style="color: #3c506c;"> <table class="Table" style="width: 100%;" border="1" width="100%" cellspacing="1"> <tbody> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">产品名称</span></strong></p> </td> <td valign="top"> <p><strong><span style="font-family: Helvetica Neue宋体;">产品编号</span></strong></p> </td> <td valign="top"> <p><strong><span style="font-family: Helvetica Neue宋体;">规格</span></strong></p> </td> <td valign="top"> <p><strong><span style="font-family: Helvetica Neue宋体;">价格</span></strong></p> </td> </tr> <tr> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">Sodium L-ascorbyl-2-phosphate</span>&nbsp;<span style="font-family: Helvetica Neue宋体;">L-抗坏血酸-2-磷酸三钠盐</span><span style="font-family: Helvetica Neue宋体;">,</span>&nbsp;<span style="font-family: Helvetica Neue宋体;">10 mM * 1 mL in Water</span></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">5864</span><span style="font-family: Helvetica Neue宋体;">8ES01</span></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">10 mM * 1 mL in Water</span></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">225</span></p> </td> </tr> </tbody> </table> </div> <p style="color: #3c506c;">&nbsp;</p> <p style="color: #3c506c;"><strong><span style="color: #f39800;"><span style="font-family: Helvetica Neue宋体;">产品描述</span></span></strong></p> <p style="color: #3c506c;"><span style="font-family: Helvetica Neue宋体;">Sodium L-ascorbyl-2-phosphate</span>&nbsp;<span style="font-family: Helvetica Neue宋体;">(L-Ascorbic acid 2-phosphate trisodium, 2-Phospho-L-ascorbic acid trisodium, Sodium ascorbyl phosphate, SAP)，也称L-抗坏血酸-2-磷酸三钠盐或维生素C磷酸酯钠，是一种维生素C衍生物，有抗氧化活性，能够促进肝细胞生长因子(HGF)的产生，促进胶原蛋白的表达和形成。</span><span style="font-family: Helvetica Neue宋体;">Sodium L-ascorbyl-2-phosphate</span><span style="font-family: Helvetica Neue宋体;">还可作为碱性磷酸酶催</span><span style="font-family: Helvetica Neue宋体;">ALP化底物，ALP表达异常与癌症、糖尿病和肝脏功能障碍等多种疾病相关</span><span style="font-family: Helvetica Neue宋体;">。</span></p> <p style="color: #3c506c;">&nbsp;</p> <p style="color: #3c506c;"><strong><span style="color: #f39800;"><span style="font-family: Helvetica Neue宋体;">产品性质</span></span></strong></p> <div class="tableResponsive" style="color: #3c506c;"> <table class="Table" style="width: 100%;" border="1" width="100%" cellspacing="1"> <tbody> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">英文别名</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">English Synonym</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">Sodium L-ascorbyl-2-phosphate</span><span style="font-family: Helvetica Neue宋体;">, L-Ascorbic acid 2-phosphate trisodium, 2-Phospho-L-ascorbic acid trisodium, Sodium ascorbyl phosphate, SAP</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">中文名称</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">Chinese Name</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">L-抗坏血酸-2-磷酸三钠盐</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">靶点</span>&nbsp;<span style="font-family: Helvetica Neue宋体;">(Target)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">Human Endogenous Metabolite</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">通路</span>&nbsp;<span style="font-family: Helvetica Neue宋体;">(Pathway)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">Immunology/Inflammation--Phosphatase</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">CAS号</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">CAS NO.</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">66170-10-3</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">分子式</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">Formula</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">C</span>_{<span style="font-family: Helvetica Neue宋体;">6</span>}<span style="font-family: Helvetica Neue宋体;">H</span>_{<span style="font-family: Helvetica Neue宋体;">6</span>}<span style="font-family: Helvetica Neue宋体;">Na</span>_{<span style="font-family: Helvetica Neue宋体;">3</span>}<span style="font-family: Helvetica Neue宋体;">O</span>_{<span style="font-family: Helvetica Neue宋体;">9</span>}<span style="font-family: Helvetica Neue宋体;">P</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">分子量</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">Molecular Weight</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">322.05</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">外观</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">Appearance</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">液体（溶于水）</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">纯度</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">Purity</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><span style="font-family: Helvetica Neue宋体;">&ge;9</span><span style="font-family: Helvetica Neue宋体;">8</span><span style="font-family: Helvetica Neue宋体;">%</span></p> </td> </tr> <tr> <td valign="center"> <p><strong><span style="font-family: Helvetica Neue宋体;">结构式</span></strong><strong>&nbsp;<span style="font-family: Helvetica Neue宋体;">(</span></strong><strong><span style="font-family: Helvetica Neue宋体;">Structure</span></strong><strong><span style="font-family: Helvetica Neue宋体;">)</span></strong></p> </td> <td valign="center"> <p><img src="https://upload.yeasen.com/file/3831/3572-171539441128401264.png" alt="" /></p> </td> </tr> </tbody> </table> </div> <p style="color: #3c506c;">&nbsp;</p> <p style="color: #3c506c;"><strong><span style="color: #f39800;"><span style="font-family: Helvetica Neue宋体;">运输和保存方法</span></span></strong></p> <p style="color: #3c506c;"><span style="font-family: Helvetica Neue宋体;">-85~-65</span><span style="font-family: Helvetica Neue宋体;">℃保存，有效期</span><span style="font-family: Helvetica Neue宋体;">1年</span><span style="font-family: Helvetica Neue宋体;">；</span><span style="font-family: Helvetica Neue宋体;">-25~-15℃</span><span style="font-family: Helvetica Neue宋体;">保存，有效期至少</span><span style="font-family: Helvetica Neue宋体;">1个月，避免反复冻融。</span></p> <p style="color: #3c506c;">&nbsp;</p> <p style="color: #3c506c;"><strong><span style="color: #f39800;"><span style="font-family: Helvetica Neue宋体;">注意事项</span></span></strong></p> <p style="color: #3c506c;"><span style="font-family: Helvetica Neue宋体;">1.</span>&nbsp;<span style="font-family: Helvetica Neue宋体;">为了您的安全和健康，请穿实验服并戴一次性手套操作。</span></p> <p style="color: #3c506c;"><span style="font-family: Helvetica Neue宋体;">2</span><span style="font-family: Helvetica Neue宋体;">.&nbsp;</span><span style="font-family: Helvetica Neue宋体;">请勿吸入</span><span style="font-family: Helvetica Neue宋体;">、</span><span style="font-family: Helvetica Neue宋体;">吞咽或者直接接触皮肤和眼睛</span><span style="font-family: Helvetica Neue宋体;">。</span></p> <p style="color: #3c506c;"><span style="font-family: Helvetica Neue宋体;">3.</span>&nbsp;<span style="font-family: Helvetica Neue宋体;">本产品仅用于科研用途，禁止用于人身上。</span></p> <p style="color: #3c506c;">&nbsp;</p> <p style="color: #3c506c;"><strong><span style="color: #f39800;"><span style="font-family: Helvetica Neue宋体;">使用浓度</span></span></strong></p> <p style="color: #3c506c;"><span class="15"><span style="font-family: Helvetica Neue宋体;">【具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。</span></span><span class="15"><span style="font-family: Helvetica Neue宋体;">】</span></span></p> <p style="color: #3c506c;"><strong><span style="font-family: Helvetica Neue宋体;">使用方法</span></strong><strong><span style="font-family: Helvetica Neue宋体;">（</span></strong><strong><span style="font-family: Helvetica Neue宋体;">数据来自于公开发表的文献，仅供参考）</span></strong></p> <p style="color: #3c506c;"><strong><span style="font-family: Helvetica Neue宋体;">细胞</span></strong><strong><span style="font-family: Helvetica Neue宋体;">实验</span></strong><strong><span style="font-family: Helvetica Neue宋体;">（体外实验）</span></strong></p> <p style="color: #3c506c;"><span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">在人角膜内皮细胞</span><span style="font-family: Helvetica Neue宋体;">(HCECs)中，</span></span><span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">L-Ascorbic acid 2-phosphate</span></span><span style="color: #212121;">&nbsp;<span style="font-family: Helvetica Neue宋体;">(0.1-1.5 mM)</span></span><span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">延长了培养的</span><span style="font-family: Helvetica Neue宋体;">HCEC的寿命</span></span><span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">，促进细胞的增殖。</span></span>^{<span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">[</span></span>}^{<span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">1</span></span>}^{<span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">]</span></span>}<span style="color: #212121;">&nbsp;<span style="font-family: Helvetica Neue宋体;">在人类脂肪干细胞</span><span style="font-family: Helvetica Neue宋体;">(hASC)中，L-Ascorbic acid 2-phosphate (50 &micro;M-250 &micro;M)促进成骨分化，增加碱性磷酸酶(ALP)活性和runx2A的表达。</span></span>^{<span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">[</span></span>}^{<span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">3</span></span>}^{<span style="color: #212121;"><span style="font-family: Helvetica Neue宋体;">]</span></span>}&nbsp;</p> <p style="color: #3c506c;">&nbsp;</p> <p style="color: #3c506c;"><strong><span style="color: #f39800;"><span style="font-family: Helvetica Neue宋体;">参考文献</span></span></strong><strong>&nbsp;&nbsp;</strong></p> <ol style="color: #3c506c;"> <li><span style="font-family: Helvetica Neue宋体;">Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7.</span></li> <li><span style="font-family: Helvetica Neue宋体;">Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003.</span></li> <li><span style="font-family: Helvetica Neue宋体;">Kyll&ouml;nen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem&ensp;Cell&ensp;Res Ther. 2013 Feb 15;4(1):17.</span></li> </ol> <p style="color: #3c506c;" align="right"><span style="font-family: Helvetica Neue宋体;">HB2</span><span style="font-family: Helvetica Neue宋体;">40428</span></p>