分子量:48.6 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human CD200, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200R1 at 2 μg/mL,the concentration of Human CD200, Fc Tag that produces 50% of the optimal binding response is appoximately 2.016 ng/mL.

产品特性:Human CD200, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 48.6 kDa. The predicted N-terminus is Gln 31. The reducing (R) protein migrates as 50-68 kDa in SDS-PAGE  due to glycosylation.

产品背景:CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.