CHUK polyclonal antibody
产品名称： CHUK polyclonal antibody
英文名称： CHUK polyclonal antibody
产品编号： PAB13399
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CHUK.
- Immunogen:
- A synthetic peptide corresponding to amino acids 716-734 of human CHUK.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- human IKK alpha differs from corresponding murine sequence by one amino acid. An 85 KDa band should be detected. This antibody has no cross response to IKKb or IKKg.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV.Science. 1997 Oct 31;278(5339):866-9.
- 2.
- A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M.Nature. 1997 Aug 7;388(6642):548-54.
- 3.
- Identification and characterization of an IkappaB kinase.
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M.Cell. 1997 Jul 25;90(2):373-83.
- Entrez GeneID:
- 1147
- Protein Accession#:
- AF009225
- Gene Name:
- CHUK
- Gene Alias:
- IKBKA,IKK-alpha,IKK1,IKKA,NFKBIKA,TCF16
- Gene Description:
- conserved helix-loop-helix ubiquitous kinase
- Omim ID:
- 600664
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq
- Other Designations:
- I-kappa-B kinase 1,I-kappa-B kinase-alpha,IKK-a kinase,IkB kinase alpha subunit,Nuclear factor NFkappaB inhibitor kinase alpha,OTTHUMP00000020273,conserved helix-loop ubiquitous kinase
- Interactome
- Gene Pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Epithelial cell signaling in Helicobacter pylori infection
- MAPK signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- T cell receptor signaling pathway
- Toll-like receptor signaling pathway
- Related Disease
- Alzheimer Disease
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Bronchiolitis, Viral
- Calcinosis
- Cardiovascular Diseases
- Cerebral Hemorrhage
- Cleft Lip
- Cleft Palate
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Fatty Liver
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hepatitis C