Active人MRP8全长蛋白质-蛋白质/抗原/多肽-试剂-生物在线

产品名称： Active人MRP8全长蛋白质

英文名称： 60B8Ag AI323541 B8Ag BEE11 CAGA Calgranulin-A Calprotectin L1L subunit Calprotectin, included CFAG CGLA Chemotactic cytokine CP-10 CP-10 Cys

产品编号： ab167749

产品价格： 0

产品产地：英国

品牌商标： abcam

更新时间： null

使用范围： null

深圳市宇德立生物科技有限公司

进入展台

Our Abpromise guarantee covers the use of ab167749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

生物活性Determined by its binding ability with Human CEACAM3 protein in the presence of 100 mM CaCl₂.
应用
SDS-PAGE

Functional Studies
内毒素水平< 1.000 Eu/µg
纯度>95% by SDS-PAGE .
ab167749 was lyophilized from 0.22 µm filtered solution.
形式Lyophilised
补充说明Determined by its binding ability with Human CEACAM3 protein in the presence of 100 mM CaCl₂.
浓度由溶解方法决定

稳定性和存储
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

pH: 7.40
Constituents: 94% PBS, 5% Trehalose

This product is an active protein and may elicit a biological response in vivo, handle with caution.
复溶It is recommended to reconstitute the lyophilized antibody in sterile deionized water to a final concentration of 1 mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.

别名
- 60B8Ag
- AI323541
- B8Ag
see all
功能Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
组织特异性Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses.
序列相似性Belongs to the S-100 family.
Contains 2 EF-hand domains.
细胞定位Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
Information by UniProt