CCR8,细胞表面趋化因子受体8抗体

产品编号HZ-10678R
英文名称CCR8
中文名称细胞表面趋化因子受体8抗体
别 名C-C chemokine receptor 8; C-C chemokine receptor type 8;CCR-8; C-C CKR-8; CC-CKR-8; CCR8; CD_antigen=CDw198.GPR-CY6; GPRCY6; Chemokine receptor-like 1; CKR-L1; TER1; CMKBRL2; CC-chemokine receptor CHEMR1; CMKBR8; CKRL1; CCR8_MOUSE.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞膜受体 趋化因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
CCR8,细胞表面趋化因子受体8抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CCR8
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4°C.
CCR8,细胞表面趋化因子受体8抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation regulated cytokine (TARC) and macrophage inflammatory protein 1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. CCR8 is also believed to be alternative coreceptor with CD4 for HIV-1 infection.

Function:
Receptor for the CCL1/SCY1/TCA-3 chemokine.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in thymus.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
1237

Database links:
Entrez Gene: 1237?/span>Human
Entrez Gene: 12776?/span>Mouse
Omim: 601834?/span>Human
SwissProt: P51685?/span>Human
SwissProt: P56484?/span>Mouse
Unigene: 113222?/span>Human
Unigene: 442098?/span>Mouse

CCR8,细胞表面趋化因子受体8抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.