CERK,神经酰胺激酶CERK抗体

产品编号HZ-10364R
英文名称CERK
中文名称神经酰胺激酶CERK抗体
别 名Acylsphingosine kinase; Ceramide kinase; hCERK; KIAA1646; Lipid kinase 4; LK4; Cerk; CERK1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CERK,神经酰胺激酶CERK抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CERK
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CERK,神经酰胺激酶CERK抗体PubMedPubMed
产品介绍background:
Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids. CERK catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This enzyme acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8 dihydroceramide), and to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. High level expression is noted in heart, brain, skeletal muscle, kidney and liver; moderate expression in peripheral blood leukocytes and thymus; and low expression in spleen, small intestine, placenta and lung.

Function:
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.

Tissue Specificity:
High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.

Similarity:
Contains 1 DAGKc domain.

Gene ID:
64781

Database links:
Entrez Gene: 64781 Human
Entrez Gene: 223753 Mouse
Entrez Gene: 300129 Rat
Omim: 610307 Human
SwissProt: Q8TCT0 Human
SwissProt: Q8K4Q7 Mouse
Unigene: 200668 Human
Unigene: 222685 Mouse
Unigene: 99537 Rat

CERK,神经酰胺激酶CERK抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.