Anti-14-3-3 sigma抗体[EPR5873(2)]-抗体-抗体-生物在线

产品名称： Anti-14-3-3 sigma抗体[EPR5873(2)]

英文名称： Anti-14-3-3 sigma抗体[EPR5873(2)]

产品编号： ab193667

产品价格： null

产品产地：英国

品牌商标： abcam

更新时间： null

使用范围：

深圳市宇德立生物科技有限公司

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描述
兔单克隆抗体[EPR5873(2)] to 14-3-3 sigma
经测试应用WB, IHC-Pmore details
种属反应性
与反应: Rat, Human
免疫原
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human 14-3-3 sigma aa 50-150. The exact sequence is proprietary.
Database link: P31947
阳性对照
- Human skin, A431 and HACAT lysates; Human 14-3-3 Sigma recombinant protein; Human tonsil tissue.
常规说明
This product is a recombinant rabbit monoclonal antibody.

Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

形式Liquid
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol, 0.05% BSA
浓度100 µl 浓度为 1.258 mg/ml 40 µl 浓度为 1.258 mg/ml 10 µl 浓度为 1.258 mg/ml
纯度Protein A purified
克隆单克隆
克隆编号EPR5873(2)
同种型IgG
研究领域

Our Abpromise guarantee covers the use of ab193667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用	Abreviews	说明
WB		1/1000 - 1/2000. Detects a band of approximately 28 kDa (predicted molecular weight: 27 kDa).
IHC-P		1/600. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

功能Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.
组织特异性Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
序列相似性Belongs to the 14-3-3 family.
翻译后修饰Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
细胞定位Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
Information by UniProt
数据库链接
- Entrez Gene: 2810 Human
- Entrez Gene: 313017 Rat
- Omim: 601290 Human
- SwissProt: P31947 Human
- Unigene: 523718 Human
别名
- 14 3 3 protein sigma antibody
- 14-3-3 protein sigma antibody
- 1433S_HUMAN antibody
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