Dopamine beta Hydroxylase,多巴胺β羟化酶抗体

产品编号HZ-0596R
英文名称Dopamine beta Hydroxylase
中文名称多巴胺β羟化酶抗体
别 名DBH; DBM; Dopamine beta hydroxylase; Dopamine-Beta-Hydroxylase; Dopamine beta monooxygenase; DOPO_RAT; DOPO_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 合成与降解
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
Dopamine beta Hydroxylase,多巴胺β羟化酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DBH
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Dopamine beta Hydroxylase,多巴胺β羟化酶抗体PubMedPubMed
产品介绍background:
Dopamine-beta-Hydroxylase (DBH), Dopamine can be transformed into Noradrenalin. Conversion of dopamine to noradrenaline. [SUBUNIT] Homotetramer composed of two non-covalently bound disulfide-linked dimers. [SUBCELLULAR LOCATION] Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein (Potential). Belongs to the copper type II ascorbate-dependent monooxygenase family.

Function:
Conversion of dopamine to noradrenaline.

Subunit:
Homotetramer composed of two non-covalently bound disulfide-linked dimers (By similarity).

Subcellular Location:
Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen (By similarity). Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen (By similarity).
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein (By similarity).

Tissue Specificity:
Chromaffin granules of the adrenal medulla and synaptic vesicles of the sympathetic nervous system.

Similarity:
Belongs to the copper type II ascorbate-dependent monooxygenase family.
Contains 1 DOMON domain.

Gene ID:
1621

Database links:
Entrez Gene: 280758 Cow
Entrez Gene: 1621 Human
Entrez Gene: 13166 Mouse
Entrez Gene: 25699 Rat
Omim: 223360 Human
Omim: 609312 Human
SwissProt: P15101 Cow
SwissProt: P09172 Human
SwissProt: Q64237 Mouse
SwissProt: Q05754 Rat
Unigene: 223858 Human
Unigene: 591890 Human
Unigene: 167781 Mouse
Unigene: 87166 Rat

Dopamine beta Hydroxylase,多巴胺β羟化酶抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Dopamine-β-Hydroxylase（DBH）—多巴胺β羟化酶。可以将多巴胺转化成去甲肾上腺素。是肾上腺素能神经元的标志。