FITC标记的神经肿瘤Nova1抗原抗体
产品名称： FITC标记的神经肿瘤Nova1抗原抗体
英文名称： Anti-Nova1/FITC
产品编号： HZ-11324R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Nova1/FITC Conjugated antibody
FITC标记的神经肿瘤Nova1抗原抗体
| 产品编号 | bs-11324R-FITC |
| 英文名称 | Anti-Nova1/FITC |
| 中文名称 | FITC标记的神经肿瘤Nova1抗原抗体 |
| 别 名 | Neuro oncological ventral antigen 1; Neuro-oncological ventral antigen 1; NOVA 1; Nova-1; Nova1; NOVA1_HUMAN; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; RNA binding protein Nova 1; RNA-binding protein Nova-1; Ventral neuron specific protein 1; Ventral neuron-specific protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nova1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5). Function: May regulate RNA splicing or metabolism in a specific subset of developing neurons. Subunit: Interacts with PTBP2; the interaction is direct (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Brain. Similarity: Contains 3 KH domains. Database links: UniProtKB/Swiss-Prot: P51513.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NoVA-1和NOVA-2是神经元中RNA代谢的蛋白调节器的超家族成员。这两个都是具有K同源基序的核RNA结合蛋白，与RNA（1，2）结合的保守蛋白序列。NOVA蛋白，通常在中枢神经系统中被隔离，是由自身免疫性疾病副肿瘤性阵发性肌阵挛肌无力共济失调（PoMA）（3，4）患者的全身性肿瘤所表达的。NoVA-1在后脑和腹侧脊髓中表达，NoVA-2在新皮层和海马中表达（4）。NOVA-1是调节甘氨酸受体α前体mRNA（5）神经元特异性剪接的必要条件。