1) Cat. No.: TRC-B675702; 2) Chemical Name: Bortezomib-D8 (Major); 3) CAS No.: ; 4) Mol. Formula: C19H17D8BN4O4; 5) Mol. Weight: 392.29; 6) Packing Size: 1mg / 10mg; 7) Appearence: Off-White to Pale Yellow Solid; 8) Application Notes: Labelled Bortezomib, whcih the first proteasome inhibitor to be approved b the US FDA for multiple myeloma, a blood cancer.  A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.
d6-3%
d7-10%
d8-86%; 9) Synonym: Velcade-D8, [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic Acid-D8; 10) Solubility: Chloroform, DMSO, Ethanol, Methanol; 11) Storage condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere; 12) References: Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005)