FITC标记的Tuberin样蛋白1抗体
产品名称： FITC标记的Tuberin样蛋白1抗体
英文名称： Anti-GARNL1/FITC
产品编号： HZ-13286R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GARNL1/FITC Conjugated antibody
FITC标记的Tuberin样蛋白1抗体
| 英文名称 | Anti-GARNL1/FITC |
| 中文名称 | FITC标记的Tuberin样蛋白1抗体 |
| 别 名 | DKFZp566D133; DKFZp667F074; GAP related interacting partner to E12; GARN L1; GARNL 1; GRIPE; GTPase activating Rap/RanGAP domain like 1; KIAA0884; Tuberin like protein 1; TULIP 1. TULIP1; RGPA1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 转运蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 230 kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GARNL1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue. Function: GTPase activating Rap/RanGAP domain-like 1 (GARNL1) is an interacting partner of the transcription factor TCF3/isoform E12, mainly in the developing embryonic forebrain. It may be an important transcriptional regulator of downstream target genes under the control of TCF3/E12, by disrupting HLH dimer formation of TCF3/E12 with other proteins and may be involved in neuronal differentiation. Subunit: Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity. Interacts with the HLH region of TCF3/isoform E12 (By similarity). Subcellular Location: Cytoplasmic and Nuclear. Translocated to the nucleus when associated with TCF3/E12. Tissue Specificity: Widely expressed. Similarity: Contains 1 Rap-GAP domain. Database links: UniProtKB/Swiss-Prot: Q6GYQ0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GARNL1在胚胎发育过程中以E12表达。在发育过程中，GARNL1表达降低，仅在成年脑神经元中维持在高水平。GARNL1定位于细胞质中，它可能起到调节蛋白质如GN和RAP的GTP水解的作用。GARNL1通过E12的二聚作用导入细胞核。GARNL1与E12的HLH区相互作用，可能对E12依赖的下游靶基因的转录起负调控作用。这表明至少一部分GARNL1的功能依赖于其与E12的关联。GARNL1也可能与其他HLH蛋白相关，并影响多种HLH信号级联。在成年脑中，GARNL1活性不涉及E12，因此它可以在发育的神经组织中发挥不同的功能。