DSCAML1,唐氏综合症细胞粘附分子2抗体

产品编号HZ-14429R
英文名称DSCAML1
中文名称唐氏综合症细胞粘附分子2抗体
别 名Down syndrome cell adhesion molecule 2; Down syndrome cell adhesion molecule like 1; Down syndrome cell adhesion molecule like protein 1; Down syndrome cell adhesion molecule-like protein 1; DSCAM2; DSCAML1; DSCL1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 神经生物学 细胞粘附分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
DSCAML1,唐氏综合症细胞粘附分子2抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量222kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DSCAML1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DSCAML1,唐氏综合症细胞粘附分子2抗体PubMedPubMed
产品介绍background:
DSCAML1 is a cell adhesion molecule that contains six Fibronectin type-III domains and ten Ig-like C2-type domains. DSCAML1 is involved in regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). DSCAML1 also promotes heteroneuronal self-avoidance to maintain mosaic spacing between aII amacrine cells. DSCAML1 is expressed in liver, skeletal muscle, brain, kidney, pancreas and heart and exists as two isoforms produced by alternative splicing events.

Function:
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Detected in heart, liver, pancreas, skeletal muscle, kidney and in brain, in particular in the amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus and subthalamus.

DSCAML1,唐氏综合症细胞粘附分子2抗体Similarity:
Contains 6 fibronectin type-III domains.
Contains 10 Ig-like C2-type (immunoglobulin-like) domains.

Gene ID:
114873

Database links:
Entrez Gene: 114873 Mouse
SwissProt: Q4VA61 Mouse
Unigene: 325499 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.