MRPS4,线粒体核糖体蛋白S4抗体

产品编号HZ-9624R
英文名称MRPS4
中文名称线粒体核糖体蛋白S4抗体
别 名BRMS2; C15orf12; Chromosome 15 open reading frame 12; imp3; IMP3_HUMAN; Mitochondrial ribosomal protein S4; MRPS4; U3 small nucleolar ribonucleoprotein protein imp3; U3 snoRNP protein 3 homolog; U3 snoRNP protein imp3.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 免疫学 发育生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit, Guinea Pig,
MRPS4,线粒体核糖体蛋白S4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human U3 small nucleolar ribonucleoprotein protein IMP3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MRPS4,线粒体核糖体蛋白S4抗体PubMedPubMed
产品介绍background:
Imp3, is a 184 amino acid protein that contains one S4 RNA-binding domain and is the mammalian homolog of the yeast Imp3 protein. Localized to the nucleus, Imp3 exists as a component of a heterotrimeric complex consisting of MPP10, Imp3 and Imp4 and, in this complex, plays a key role in early cleavage events during pre-18S ribosomal processing. The gene encoding Imp3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Subunit:
Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.

Subcellular Location:
Nucleus, nucleolus.

Similarity:
Belongs to the ribosomal protein S4P family.
Contains 1 S4 RNA-binding domain.

Gene ID:
55272

Database links:
Entrez Gene: 55272 Human
Entrez Gene: 102462 Mouse
Entrez Gene: 315697 Rat
Omim: 612980 Human
SwissProt: Q9NV31 Human
SwissProt: Q921Y2 Mouse
Unigene: 513043 Human
Unigene: 12864 Mouse

MRPS4,线粒体核糖体蛋白S4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.