分子量:112.3 kDa

纯度:>92% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Jagged 1, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human Jagged 1, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 112.3 kDa. The predicted N-terminus is Gln 34. The reducing (R) protein migrates as 160-180 kDa in SDS-PAGE  due to glycosylation.

产品背景:Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).