RANKL Rabbit pAb
产品名称： RANKL Rabbit pAb
英文名称： RANKL Rabbit pAb
产品编号： 31430ES50
产品价格： 1285.00
产品产地： Yeasen
品牌商标： Yeasen
更新时间： 2024-01-19T09:19:02
使用范围： null
| 规格 | 价格 |
| 50 µl | 1285.0 |
| 100 µl | 2285.0 |
- 联系人 : 李自转
- 地址 : 上海市浦东新区天雄路166弄一号楼三层南单元
- 邮编 : 200030
- 所在区域 : 上海
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产品信息
|
产品名称 |
产品编号 |
规格 |
|
RANKL Rabbit pAb |
31430ES50 |
50 μL |
|
31430ES60 |
100 μL |
产品简介
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy.
产品性质
|
别名 |
TNFSF11; OPGL; RANKL; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induc |
|
SwissProt ID |
O14788 |
|
基因ID |
8600 |
|
免疫原 |
The antiserum was produced against synthesized peptide derived from the C-terminal region of human TNFSF11. |
|
缓冲液 |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
|
分子量 |
Calculated MW: 35 kDa; Observed MW: 35 kDa |
|
克隆类型 |
Polyclonal Antibody |
|
亚型 |
IgG |
|
克隆号 |
- |
|
宿主 |
Rabbit |
|
物种反应 |
Human, Mouse, Rat |
|
推荐应用 |
WB, IHC-P, ELISA |
|
纯化方式 |
Affinity Purified |
应用
稀释比 WB:1/500-1/1000; IHC:1/50-1/100; ELISA: 1/10000
储存条件
-25~-15℃保存
注意事项
1. 避免反复冻融。
2. 本产品仅作科研用途。
3. 为了您的安全和健康，请穿实验服并佩戴一次性手套操作。
Ver.CN20231229