CCDC104,卷曲螺旋结构域蛋白104抗体

产品编号HZ-8103R
英文名称CCDC104
中文名称卷曲螺旋结构域蛋白104抗体
别 名CC104_HUMAN; CCDC104; Coiled coil domain containing 104; Coiled-coil domain-containing protein 104; MGC15407.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
CCDC104,卷曲螺旋结构域蛋白104抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CCDC104
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
CCDC104,卷曲螺旋结构域蛋白104抗体PubMedPubMed
产品介绍background:
CCDC104 is a 342 amino acid protein that exists as two alternatively spliced isoforms. CCDC104 undergoes post-translational phosphorylation following DNA damage, most likely by either ATR or ATM. The gene encoding CCDC104 maps to human chromosome 2, the second largest human chromosome, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome is due to mutations in the ALMS1 gene.

Function:
May act as an effector for ARL3.

Subunit:
Interacts with ARL3.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Database links:
UniProtKB/Swiss-Prot: Q96G28.2

CCDC104,卷曲螺旋结构域蛋白104抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.