FITC标记的PSF2蛋白抗体
产品名称： FITC标记的PSF2蛋白抗体
英文名称： Anti-PSF2/FITC
产品编号： HZ-7824R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PSF2/FITC Conjugated antibody
FITC标记的PSF2蛋白抗体
| 英文名称 | Anti-PSF2/FITC |
| 中文名称 | FITC标记的PSF2蛋白抗体 |
| 别 名 | GINS complex subunit 2; GINS2; HSPC037; PSF2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSF2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The GINS complex is composed of four subunits, encoded by SLD5, PSF1, PSF2, and PSF3. In S. cerevisiae, it was first identified by genetic and biochemical methods to determine factors interacting with Sld5p. Genetic interactions between these four genes also suggest that they act together. The GINS complex was independently isolated in a large scale screen for cell cycle defects. A similar complex is found in Xenopus and has a ring-like structure. In yeast, all four genes are essential and cells defective in SLD5, PSF1, or PSF2 are impaired in their ability to replicate DNA. The complex localizes to origins of DNA replication and Sld5p was previously implicated as functioning in DNA replication due to its genetic interaction with DPB11. Additional genetic and biochemical interactions of the GINS complex with Dpb11p, Dpb2p, and Sld3p suggest that it functions in some way at the replication fork during DNA synthesis. Function: The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-strandedDNA. Subunit: Component of the GINS complex which is a heterotetramerof GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex withGINS3. GINS complex interacts with DNA primase in vitro. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the GINS2/PSF2 family. Database links: Entrez Gene: 415824 Chicken Entrez Gene: 609436 Dog Entrez Gene: 51659 Human Entrez Gene: 272551 Mouse Entrez Gene: 292058 Rat Entrez Gene: 444053 Xenopus laevis Entrez Gene: 554146 Zebrafish Omim: 610609 Human SwissProt: Q9Y248 Human SwissProt: Q9D600 Mouse SwissProt: Q7ZT46 Xenopus laevis Unigene: 433180 Human Unigene: 275910 Mouse Unigene: 3786 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GIN复合物由四个亚基组成，由SLD5、PSF1、PSF2和PSF3编码。在酿酒酵母中，它首先通过遗传和生化方法鉴定以确定与SLD5P相互作用的因素。这四个基因之间的遗传相互作用也表明它们共同作用。GIN复合物在细胞周期缺陷的大规模筛网中被独立地分离。在Xenopus发现类似的复合物，并具有环状结构。在酵母中，所有四个基因都是必需的，并且在SLD5、PSF1或PSF2中有缺陷的细胞在复制DNA的能力方面受损。复杂的本地化DNA复制的起源和SLD5P先前被牵连在DNA复制中的功能，因为其与DPB11的遗传相互作用。GNIs复合物与DPB11P、DPB2P和SLD3P的额外遗传和生化相互作用表明它在DNA合成过程中以某种方式在复制叉上起作用。