FITC标记的2'-5'-寡腺苷酸合成酶3抗体
产品名称： FITC标记的2'-5'-寡腺苷酸合成酶3抗体
英文名称： Anti-OAS3/FITC
产品编号： HZ-7344R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-OAS3/FITC Conjugated antibody
FITC标记的2'-5'-寡腺苷酸合成酶3抗体
| 英文名称 | Anti-OAS3/FITC |
| 中文名称 | FITC标记的2'-5'-寡腺苷酸合成酶3抗体 |
| 别 名 | (2-5'')oligo(A) synthase 3; 2 5' oligo(A) synthetase 3; 2 5'LIGO; 2 5A synthetase 3; 2''-5''-oligoadenylate synthase 3; 2-5A synthase 3; MGC133260; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa; OAS3; OAS3_HUMAN; p100; p100 OAS; p100OAS. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OAS3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The 2'- 5'- oligoadenylate synthetase (OAS) family is comprised of four members: OAS1, OAS2, OAS3 and OASL. These proteins are induced by interferons and function to convert ATP into 2'- 5'- linked oligomers of adenosine in the presence of double-stranded RNA and magnesium ions. Copper, iron and zinc ions strongly inhibit the OAS enzymatic activity, while manganese ions can replace magnesium ions as an activator. The OAS family plays a significant role in the inhibition of cellular protein synthesis, apoptosis and growth, and its members are important factors in viral infection resistance. OAS3, also referred to as p100, contains three adjacent OAS1-like domains and maps to the human chromosome 12q24.2 Function: May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. Tissue Specificity: Present at high level in placenta trophoblast. Similarity: Belongs to the 2-5A synthase family. Database links: Entrez Gene: 4940 Human Omim: 603351 Human SwissProt: Q9Y6K5 Human Unigene: 528634 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
2’-5’-寡腺苷酸合成酶（OAS）家族由四个成员组成：OAS1、OAS2、OAS3和OASL。这些蛋白由干扰素诱导，在双链RNA和镁离子的存在下能将ATP转化为2'-5'-连接的腺苷低聚物。铜、铁和锌离子强烈抑制OAS酶活性，而锰离子可以取代镁离子作为活化剂。OAS家族在抑制细胞蛋白合成、凋亡和生长中起重要作用，其成员是病毒感染抵抗的重要因素。OAS3，也称为P100，包含三个相邻的OAS1样结构域，并映射到人类染色体12q24.2。