分子量:38.8 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Decorin, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:Measured by its ability to modulate collagen fibrillogenesis.  At 5 g/mL, rhDecorin can significantly delay the rate of type I collagen fibrillogenesis.

产品特性:Human Decorin, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 38.8 kDa. The predicted N-terminus is Gly 17. The reducing (R) protein migrates as 45kDa or higher  in SDS-PAGE  due to different  glycosylation.

产品背景:Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).