FITC标记的细胞纤毛内转运同源蛋白122抗体
产品名称： FITC标记的细胞纤毛内转运同源蛋白122抗体
英文名称： Anti-IFT122/FITC
产品编号： HZ-15558R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IFT122/FITC Conjugated antibody
FITC标记的细胞纤毛内转运同源蛋白122抗体
| 英文名称 | Anti-IFT122/FITC |
| 中文名称 | FITC标记的细胞纤毛内转运同源蛋白122抗体 |
| 别 名 | CED; IF122_HUMAN; IFT122; Intraflagellar transport 122 homolog (Chlamydomonas); Intraflagellar transport protein 122 homolog; SPG; WD repeat domain 10; WD repeat-containing protein 10; WD repeat-containing protein 140; WDR10; WDR10p; WDR140. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 142kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFT122 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IFT122 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Function: Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). Subunit: Component of the IFT complex A (IFT-A) complex. Subcellular Location: Cytoplasm. Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Localizes to photoreceptor connecting cilia (By similarity). Tissue Specificity: Expressed in many tissues. Predominant expression in testis and pituitary. DISEASE: Cranioectodermal dysplasia 1 (CED1) [MIM:218330]: A disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include dolichocephaly (with or without sagittal suture synostosis), scaphocephaly, short stature, limb shortening, short ribs, narrow chest, brachydactyly, renal failure and hepatic fibrosis, small and abnormally shaped teeth, sparse hair, skin laxity and abnormal nails. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 7 WD repeats. Database links: UniProtKB/Swiss-Prot: Q9HBG6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IFT122是WD重复蛋白家族的成员。WD重复序列是大约40个氨基酸的最小保守区域，通常由gly-his和trp-asp(GH-WD)包围，这可能促进异三聚或多蛋白复合物的形成。该家族的成员参与多种细胞过程，包括细胞周期进程、信号转导、凋亡和基因调控。该细胞质蛋白包含7个WD重复序列和一个AF-2结构域，该结构域通过募集共调节分子和在转录激活中起作用。编码不同的异构体的交替转录剪接变异体已被表征。