分子量:28 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human CD155, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:Measure by its ability to bind with recombinant human DNAM1 / CD226 in a functional ELISA assay.

产品特性:Human CD155, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 28 kDa. The predicted N-terminus is Trp 21. The reducing (R) protein migrates as 50-65 kDa in SDS-PAGE  due to glycosylation.

产品背景:CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.
CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. 
CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.