分子量:14.6 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Transthyretin, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:Measured by its ability to bind biotinylated human RBP4 in a functional ELISA.

产品特性:Human Transthyretin, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 14.6 kDa. The predicted N-terminus is Gly 21. The reducing (R) protein migrates as 19 kDa and 37kDa in SDS-PAGE  due to the monomer and dimer respectively.

产品背景:Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.