FITC标记的微管关联蛋白RP/EB家族成员1抗体
产品名称： FITC标记的微管关联蛋白RP/EB家族成员1抗体
英文名称： Anti-MAPRE1/FITC
产品编号： HZ-18675R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
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- 所在区域 : 上海
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Rabbit Anti-MAPRE1/FITC Conjugated antibody
FITC标记的微管关联蛋白RP/EB家族成员1抗体
| 英文名称 | Anti-MAPRE1/FITC |
| 中文名称 | FITC标记的微管关联蛋白RP/EB家族成员1抗体 |
| 别 名 | 5530600P05Rik; Adenomatous polyposis coli binding protein EB 1; Adenomatous polyposis coli binding protein EB1; AI462499; AI504412; APC binding protein EB 1; APC binding protein EB1; APC-binding protein EB1; AW260097; BIM1p; D2Ertd459e; EB 1; EB1; End binding protein 1; End-binding protein 1; fa01e12; fc23e11; fi33c06; MAPRE 1; MAPRE1; Mapre3; MARE1_HUMAN; MGC117374; MGC129946; MGC52508; Microtubule associated protein RP/EB family member 1; Microtubule-associated protein RP/EB family member 1; wu:fa01e12; wu:fc23e11; wu:fi33c06; zgc:55428; zgc:77807; zgc:85755. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAPRE1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008] Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. Subcellular Location: Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the MAPRE family. Contains 1 CH (calponin-homology) domain. Contains 1 EB1 C-terminal domain. Database links: Entrez Gene: 22919 Human Entrez Gene: 419288 Chicken Entrez Gene: 13589 Mouse Entrez Gene: 100173206 Orangutan Entrez Gene: 114764 Rat Omim: 603108 Human SwissProt: Q5ZLC7 Chicken SwissProt: Q15691 Human SwissProt: Q61166 Mouse SwissProt: Q5R7Z5 Orangutan SwissProt: Q6V291 Quail SwissProt: Q66HR2 Rat Unigene: 472437 Human Unigene: 143877 Mouse Unigene: 7652 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白首先通过与APC蛋白的结合而被鉴定，APC蛋白在家族性和散发性结直肠癌中经常发生突变。在间期细胞中，这种蛋白质定位为微管，特别是生长端。在有丝分裂过程中，蛋白质与中心体和纺锤体微管相关。该蛋白还与DyaCin复合物和胞质动力蛋白中间链相关。由于这些联系，人们认为这种蛋白参与微管结构和染色体稳定性的调节。该基因是RP/EB家族的成员。[ RefSeq，JUL 2008 ]