分子量:40.5 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human CD5, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human CD5, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 40.5 kDa. The predicted N-terminus is Arg 25. The reducing (R) protein migrates as 48-55 kDa in SDS-PAGE  due to glycosylation.

产品背景:T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.