FITC标记的磷酸化丝裂原活化蛋白激酶激酶2抗体
产品名称： FITC标记的磷酸化丝裂原活化蛋白激酶激酶2抗体
英文名称： Anti-phospho-MEK2(Ser226)/FITC
产品编号： HZ-5498R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-MEK2(Ser226)/FITC Conjugated antibody
FITC标记的磷酸化丝裂原活化蛋白激酶激酶2抗体
| 英文名称 | Anti-phospho-MEK2(Ser226)/FITC |
| 中文名称 | FITC标记的磷酸化丝裂原活化蛋白激酶激酶2抗体 |
| 别 名 | MAP2K2(phospho S226); Cardiofaciocutaneous syndrome; CFC syndrome; Dual specificity mitogen activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAP2K 2; map2k2; MAPK / ERK kinase 2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; Microtubule Associated Protein Kinase Kinase 2; Mitogen activated protein kinase kinase 2; Mitogen activated protein kinase kinase 2 p45; MKK 2; MKK2; MP2K2_HUMAN; OTTHUMP00000165826; OTTHUMP00000165827; PRKMK 2; PRKMK2 V. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 免疫学 信号转导 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human MEK2 around the phosphorylation site of Ser226 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]. Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Subunit: Interacts with MORG1 (By similarity). Interacts with SGK1. Post-translational modifications: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1. Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. DISEASE: Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 407835 Human Entrez Gene: 5605 Human Entrez Gene: 26396 Mouse Entrez Gene: 58960 Rat Omim: 601263 Human SwissProt: P36507 Human SwissProt: Q63932 Mouse SwissProt: P36506 Rat Unigene: 465627 Human Unigene: 275436 Mouse Unigene: 82693 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
由该基因编码的蛋白质是属于MAP激酶家族的双特异性蛋白激酶。已知该激酶在丝裂原生长因子信号转导中起关键作用。它磷酸化，从而激活MAPK1/Erk2和MAPK2/Erk3。该激酶本身的激活依赖于MAP激酶激酶激酶的SR/THR磷酸化。该基因的突变导致心肌皮肤综合征（CFC综合征），该疾病的特征是心脏缺陷、智力低下和与NoNANA综合征相似的独特的面部特征。这种激酶的抑制或降解也参与了Yersinia和炭疽的发病机制。一个假基因，位于7号染色体上，已被鉴定为该基因。[ RefSeq，JUL 2008 ]提供。