KIAA2022,KIAA2022蛋白抗体

产品编号HZ-17033R
英文名称KIAA2022
中文名称KIAA2022蛋白抗体
别 名Protein KIAA2022; expressed sequence C77370; K2022_HUMAN; Kiaa2022; RP11-130N24.1; RP23-35L3.1; Uncharacterized protein KIAA2022.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 发育生物学 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Horse,
KIAA2022,KIAA2022蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量167kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Protein KIAA2022
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
KIAA2022,KIAA2022蛋白抗体PubMedPubMed
产品介绍background:
KIAA2022 is a 1,516 amino acid protein that is highly expressed in both adult and fetal brain and is encoded by a gene which maps to human chromosome X. Chromosomal aberrations involving the KIAA2022 gene are associate with the development of severe mental retardation, suggesting a role for KIAA2022 in normal brain development and function. Human chromosome X, on which the KIAA2022 gene is localized, contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.

Tissue Specificity:
Highly expressed in fetal and adult brain, predominantly in the cerebral cortex and the cerebellum. Also expressed in other tissues but to a lesser extent.

DISEASE:
Note=A chromosomal aberration involving KIAA2022 is found in 2 patients with severe mental retardation (MR). Pericentric inversion inv(X)(p22.3;q13.2). The Xq13 breakpoint lies within a predicted intron of KIAA2022 gene. KIAA2022 protein is no longer expressed in these patients lymphocytes.

Gene ID:
340533

Database links:
Entrez Gene: 340533 Human
Omim: 300524 Human
SwissProt: Q5QGS0 Human
Unigene: 124128 Human
Entrez Gene: 100173017 Orangutan
Entrez Gene: 100155718 Pig
Entrez Gene: 716288 Rhesus monkey
Omim: 607359 Human
SwissProt: Q8N163 Human
SwissProt: Q8VDP4 Mouse
SwissProt: Q5R8S0 Orangutan
Unigene: 433722 Human

KIAA2022,KIAA2022蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.