CAIV/Carbonic Anhydrase IV,碳酸酐酶4抗体

产品编号HZ-8722R
英文名称CAIV/Carbonic Anhydrase IV
中文名称碳酸酐酶4抗体
别 名CA IV; CA4; CAH4_HUMAN; CAIV; Car4; Carbonate dehydratase IV; Carbonic anhydrase 4; Carbonic dehydratase; Carbonic dehydratase IV; EC 4.2.1.1; Retinitis pigmentosa 17 (autosomal dominant); RP17.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 干细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CAIV/Carbonic Anhydrase IV,碳酸酐酶4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CAIV/Carbonic Anhydrase IV
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CAIV/Carbonic Anhydrase IV,碳酸酐酶4抗体PubMedPubMed
产品介绍background:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]

Function:
Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.

Subunit:
Interacts with SLC4A4.

Subcellular Location:
Cell membrane; Lipid-anchor › GPI-anchor

Tissue Specificity:
Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels.

CAIV/Carbonic Anhydrase IV,碳酸酐酶4抗体DISEASE:
The disease is caused by mutations affecting the gene represented in this entry. Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.
Disease description:A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Similarity:
Belongs to the alpha-carbonic anhydrase family.

Gene ID:
762

Database links:
Entrez Gene: 762 Human
Entrez Gene: 12351 Mouse
Omim: 114760 Human
SwissProt: P22748 Human
SwissProt: Q64444 Mouse
Unigene: 89485 Human
Unigene: 1641 Mouse

CAIV/Carbonic Anhydrase IV,碳酸酐酶4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.