PGCP,血浆谷氨酸羧肽酶抗体

产品编号HZ-9917R
英文名称PGCP
中文名称血浆谷氨酸羧肽酶抗体
别 名Plasma glutamate carboxypeptidase; CBPQ_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 信号转导 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit,
PGCP,血浆谷氨酸羧肽酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PGCP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PGCP,血浆谷氨酸羧肽酶抗体PubMedPubMed
产品介绍background:
PGCP is a 472 amino acid secreted protein that is primarily detected in blood plasma. PGCP is a carboxypeptidase that potentially is involved in the hydrolysis of circulating peptides. Due to its upregulation in hepatocellular carcinoma (HCC), it is suspected that PGCP may be a potential serological marker for HCC. PGCP is a member of the Peptidase M28 family of proteins, which also includes PSM (prostate-specific membrane antigen), metallopeptidases and aminopeptidases. The gene encoding PGCP maps to chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis.In humans, PGCP is found principally in blood plasma. It is a Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides.

Function:
Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes more efficiently the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in thyroxin hormone liberation from its TG/thyroglobulin precursor.

Subunit:
Homodimer. The monomeric form is inactive while the homodimer is active.

Subcellular Location:
Secreted.

Tissue Specificity:
Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level).

Post-translational modifications:
N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).

Similarity:
Belongs to the peptidase M28 family.

PGCP,血浆谷氨酸羧肽酶抗体Database links:
Entrez Gene: 10404 Human
Entrez Gene: 54381 Mouse
Entrez Gene: 58952 Rat
SwissProt: Q9Y646 Human
SwissProt: Q9WVJ3 Mouse
SwissProt: Q6IRK9 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.