CHIA,哺乳动物酸性几丁质酶抗体

产品编号HZ-13900R
英文名称CHIA
中文名称哺乳动物酸性几丁质酶抗体
别 名Acidic mammalian chitinase [Precursor]; AMCase; CHIT2; chitinase, acidic; DKFZp313J1722; ECF L; RP5 1125M8.1; TSA1902.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Zebrafish, Sheep,
CHIA,哺乳动物酸性几丁质酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CHIA
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CHIA,哺乳动物酸性几丁质酶抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Function:
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.

Subcellular Location:
Isoform 1: Secreted Isoforms 2 and 3: Cytoplasmic

Similarity:

Database links:
Entrez Gene: 27159 Human
Entrez Gene: 81600 Mouse
Entrez Gene: 113901 Rat
GenBank: NM_021797.2 Human
Omim: 606080 Human
SwissProt: Q9BZP6 Human
SwissProt: Q91XA9 Mouse
SwissProt: Q6RY07 Rat
Unigene: 46418 Mouse

CHIA,哺乳动物酸性几丁质酶抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.