FAIM2,FAS凋亡抑制分子2抗体

产品编号HZ-6831R
英文名称FAIM2
中文名称FAS凋亡抑制分子2
别 名FAIM 2; Fas apoptotic inhibitory molecule 2; LFG; Lifeguard; Neural membrane protein 35; NGP 35; NGP35; NMP 35; NMP35; Protein lifeguard; TMBIM 2; TMBIM2; Transmembrane BAX inhibitor motif containing 2; Transmembrane BAX inhibitor motif containing protein 2; LFG2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, Monkey,
FAIM2,FAS凋亡抑制分子2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FAIM2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FAIM2,FAS凋亡抑制分子2抗体PubMedPubMed
产品介绍background:
Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.

Function:
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

Subunit:
Interacts with FAS/TNFRSF6 and BAX.

FAIM2,FAS凋亡抑制分子2抗体Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity). Membrane raft. Cell junction, synapse, postsynaptic cell membrane (By similarity).

Tissue Specificity:
Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.

Similarity:
Belongs to the BI1 family. LFG subfamily.

Gene ID:
23017

Database links:
Entrez Gene: 23017 Human
Entrez Gene: 72393 Mouse
Entrez Gene: 246274 Rat
Omim: 604306 Human
SwissProt: Q9BWQ8 Human
SwissProt: Q8K097 Mouse
SwissProt: O88407 Rat
Unigene: 567424 Human
Unigene: 39760 Mouse
Unigene: 162026 Rat

FAIM2,FAS凋亡抑制分子2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.