FITC标记的磷酸化补体成分5受体1抗体
产品名称： FITC标记的磷酸化补体成分5受体1抗体
英文名称： Anti-phospho-C5R1 (Ser338)/FITC
产品编号： HZ-13816R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-C5R1 (Ser338)/FITC Conjugated antibody
FITC标记的磷酸化补体成分5受体1抗体
| 英文名称 | Anti-phospho-C5R1 (Ser338)/FITC |
| 中文名称 | FITC标记的磷酸化补体成分5受体1抗体 |
| 别 名 | C5R1 (phospho S338); p-C5R1 (phospho S338); ANAPHYLATOXIN RECEPTOR; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin receptor; C5A; C5a ligand; C5a-R; C5aR; C5AR_HUMAN; c5ar1; C5R1; CD88; CD88 antigen; Complement component 5 receptor 1; Complement component 5 receptor 1; Complement component 5 receptor 2; Complement component 5a receptor 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 新陈代谢 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human C5R1 around the phosphorylation site of (Ser338). |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CD88, also known as C5a receptor (C5aR), is a G protein-coupled integral membrane protein. CD88, which is expressed on neutrophils, monocytes, macrophages, hepatocytes and mast cells, as well as on various epithelial and endothelial cells, serves as a receptor for the inflammatory peptide C5a. Research studies suggest a role for CD88 in the inflammatory response. The binding of C5a to CD88 has been shown to elicit increased production of acute phase proteins in liver. In brain, an increased production of CD88 has been shown to be associated with inflammation. Research also indicates a role for C5a/C5aR in the pathogenesis of rheumatoid arthritis, as well as a heightened responsiveness of human bronchial epithelial cells (HBECs) to C5a upon exposure of these cells to cigarette smoke and other environmental irritants. Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Subcellular Location: Cell membrane. Post-translational modifications: Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 728 Human Entrez Gene: 12273 Mouse Omim: 113995 Human SwissProt: P21730 Human SwissProt: P30993 Mouse SissProt: Q3TZ86 Mouse Unigene: 2161 Human Unigene: 247623 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CD88，也称为C5a受体（C5AR），是G蛋白偶联的整合膜蛋白。CD88表达于中性粒细胞、单核细胞、巨噬细胞、肝细胞和肥大细胞以及各种上皮细胞和内皮细胞上，是炎性肽C5a的受体。研究表明CD88在炎性反应中起作用。C5a与CD88的结合已被证明引起肝脏中急性相蛋白的增加。在大脑中，CD88的增加的产生已被证明与炎症有关。研究还表明C5a/C5aR在类风湿性关节炎的发病机制中的作用，以及当这些细胞暴露于香烟烟雾和其他环境刺激物时，人支气管上皮细胞(HBEC)对C5a的响应性增强。