MKP1 (S355) Antibody-抗体-抗体-生物在线
巴傲得生物科技有限公司
MKP1 (S355) Antibody

MKP1 (S355) Antibody

商家询价

产品名称: MKP1 (S355) Antibody

英文名称: MKP1 (S355) Antibody

产品编号: BS1677

产品价格: null

产品产地: USA

品牌商标: Bioworld

更新时间: null

使用范围: WB: 1:500~1:1000 IHC: 1:50~1:200

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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.