MKP1 (S355) Antibody
产品名称: MKP1 (S355) Antibody
英文名称: MKP1 (S355) Antibody
产品编号: BS1677
产品价格: null
产品产地: USA
品牌商标: Bioworld
更新时间: null
使用范围: WB: 1:500~1:1000 IHC: 1:50~1:200
巴傲得生物科技有限公司
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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.