FITC标记的磷酸化红细胞膜条带4.1蛋白抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的磷酸化红细胞膜条带4.1蛋白抗体

FITC标记的磷酸化红细胞膜条带4.1蛋白抗体

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产品名称： FITC标记的磷酸化红细胞膜条带4.1蛋白抗体

英文名称： Anti-phospho-EPB41 (Tyr418 + Tyr660)/FITC

产品编号： HZ-13081R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-phospho-EPB41 (Tyr418 + Tyr660)/FITC Conjugated antibody

FITC标记的磷酸化红细胞膜条带4.1蛋白抗体

 

英文名称 Anti-phospho-EPB41 (Tyr418 + Tyr660)/FITC
中文名称 FITC标记的磷酸化红细胞膜条带4.1蛋白抗体
别    名 EPB41 (phospho Y418 + Y660); EPB41 (phospho Tyr418 + Tyr660); p-EPB41 (Y418 + Y660); p-4p-EPB41 (Tyr418 + Tyr660); 4.1R; 41_HUMAN; Band 4.1; E41P; EL 1; EL1; Elliptocytosis 1; Elliptocytosis 1 RH linked; EPB 4.1; EPB 41; EPB4.1; Epb41; Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked); Erythrocyte membrane protein band 4.1; Erythrocyte surface protein band 4.1; HE; P4.1; Protein 4.1.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 细胞生物  信号转导  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human EPB41 around the phosphorylation site of Tyr418 + Tyr660
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The 4.1 gene family encodes a group of multifunctional cytoskeletal proteins (4.1R, 4.1G, 4.1N and 4.1B), which are predominantly expressed in the nervous system. 4.1G is a protein that stabilizes spectrin-actin interactions and is associated with hereditary elliptocytosis. Red blood cell 4.1, designated 4.1R, is a multifunctional protein that is essential for maintaining erythrocyte shape and membrane mechanical properties. Both 4.1R and 4.1G are distributed in a unique pattern in the cerebellum and are believed to modulate the membrane mechanical properties of neuronal cells by promoting fodrin/actin association. 4.1N and 4.1B, designated EPB41L1 and EPB41L3, respectively, are strongly expressed in the brain. Antibodies to 4.1N have been reported to detect mulitple forms, each enriched in postsynaptic density preparations relative to brain homogenate. Antibodies to 4.1B have been reported to detect two forms.

Function:
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.

Subunit:
Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions.

Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Nucleus.

Post-translational modifications:
Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.

DISEASE:
Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.

Similarity:
Contains 1 FERM domain.

Database links:
UniProtKB/Swiss-Prot: P11171.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

4.1基因家族编码一组多功能细胞骨架蛋白(4.1R、4.1G、4.1N和4.1B)，主要表达于神经系统。4.1G是稳定光谱学-肌动蛋白相互作用的蛋白，与遗传性椭圆形红细胞增多症有关。红细胞4.1，称为4.1R，是维持红细胞形状和膜机械性能所必需的多功能蛋白。4.1R和4.1G都以独特的方式分布在小脑中，并且被认为通过促进叶黄素/肌动蛋白的结合来调节神经元细胞的膜机械特性。4.1N和4.1b，分别为EPB41L1和EPB41L3，在大脑中强烈表达。据报道，抗4.1N的抗体可以检测多种形式，每种形式都富含与脑匀浆有关的突触后密度制剂。已经报道了4.1b的抗体检测两种形式。