FITC标记的乙酰胆碱酯酶抗体
产品名称： FITC标记的乙酰胆碱酯酶抗体
英文名称： Anti-ACHE/FITC
产品编号： HZ-2511R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-ACHE/FITC Conjugated antibody
FITC标记的乙酰胆碱酯酶抗体
| 英文名称 | Anti-P450 1A2/FITC |
| 中文名称 | FITC标记的细胞色素P450 1A2抗体 |
| 别 名 | CYP1A2; Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; Cyp1a2; CYPD45; P-450d; RATCYPD45; CYP1A2; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 合成与降解 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human P450 1A2/CYP1A2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu region. [provided by RefSeq].sequences flanked by direct repeats in the 3' untranslated. Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Subcellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Tissue Specificity: Liver. Similarity: Belongs to the cytochrome P450 family. Database links: Entrez Gene: 1544 Human Entrez Gene: 13077 Mouse Entrez Gene: 24297 Rat Omim: 124060 Human SwissProt: P05177 Human SwissProt: P00186 Mouse SwissProt: P04799 Rat Unigene: 1361 Human Unigene: 15537 Mouse Unigene: 5563 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） |
Acetylcholinesterase水解神经递质、乙酰胆碱在神经肌肉接头和脑胆碱能突触，从而终止信号传递。它也存在于红细胞膜上，在那里构成YT血型抗原。乙酰胆碱酯酶存在于具有相似催化性质的多个分子形式中，但在它们的寡聚体组装和细胞附着到细胞表面的方式上是不同的。它由单个AChE基因编码，基因产物的结构多样性来自选择性mRNA剪接，以及催化和结构亚基的翻译后关联。在脑、肌肉和其他组织中发现的乙酰胆碱酯酶的主要形式是亲水性物种，其形成具有胶原或含脂质结构亚基的二硫键低聚物。另一种，选择性剪接形式，主要表达在红系组织中，在C-末端不同，并且包含具有GPI锚定位点的可裂解疏水肽。它通过翻译后添加的磷脂酰肌醇（PI）部分与膜结合。