SNCA polyclonal antibody
产品名称： SNCA polyclonal antibody
英文名称： SNCA polyclonal antibody
产品编号： PAB4478
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SNCA.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SNCA.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody is specific to SNCA isoform NACP112 and NCAP140.
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations.
Kumru H, Santamaria J, Tolosa E, Valldeoriola F, Munoz E, Marti MJ, Iranzo A.Ann Neurol. 2004 Oct;56(4):599-603.
- 2.
- Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor.
Pigullo S, De Luca A, Barone P, Marchese R, Bellone E, Colosimo A, Scaglione C, Martinelli P, Di Maria E, Pizzuti A, Abbruzzese G, Dallapiccola B, Ajmar F, Mandich P.Parkinsonism Relat Disord. 2004 Aug;10(6):357-62.
- 3.
- Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA.Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10810-4. Epub 2004 Jul 13.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of SNCA polyclonal antibody (Cat # PAB4478) in mouse brain tissue lysate . SNCA (arrow) was detected using the purified SNCA polyclonal antibody (Cat # PAB4478) .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with SNCA polyclonal antibody (Cat # PAB4478) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .
- Entrez GeneID:
- 6622
- Protein Accession#:
- NP_009292.1
- Gene Name:
- SNCA
- Gene Alias:
- MGC110988,NACP,PARK1,PARK4,PD1
- Gene Description:
- synuclein, alpha (non A4 component of amyloid precursor)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000161559,OTTHUMP00000161561,alpha synuclein,alpha-synuclein,alpha-synuclein, isoform NACP140,non A-beta component of AD amyloid,non A4 component of amyloid
- Interactome
- Gene Pathway
- Related Disease
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Amphetamine-Related Disorders
- Association Learning
- Attention
- Cardiovascular Diseases
- Chromosome Breakage
- Cognition Disorders
- Color Perception
- Cystic Fibrosis
- Cystic fibrosis
- Dementia
- Diabetes Complications
- Disease Progression
- Disease Susceptibility
- Essential Tremor
- Essential tremor
- Genetic Predisposition to Disease