FITC标记的神经连接蛋白2抗体
产品名称： FITC标记的神经连接蛋白2抗体
英文名称： Anti-NLGN2/FITC
产品编号： HZ-11098R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NLGN2/FITC Conjugated antibody
FITC标记的神经连接蛋白2抗体
| 产品编号 | bs-11098R-FITC |
| 英文名称 | Anti-NLGN2/FITC |
| 中文名称 | FITC标记的神经连接蛋白2抗体 |
| 别 名 | NL2; Neuroligin 2; Ortholog of human and rat neuroligin 2 NLGN2. KIAA1366; MGC67386; RP23-422L16.24; NLGN2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 神经生物学 细胞粘附分子 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 90kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NLGN1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses. Function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with INADL. Interacts with GPHN. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina. Tissue Specificity: Expressed in the blood vessel walls. Detected in colon, brian and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. Similarity: Belongs to the type-B carboxylesterase/lipase family. Database links: Entrez Gene: 57555 Human Entrez Gene: 216856 Mouse Entrez Gene: 117096 Rat Omim: 606479 Human SwissProt: Q8NFZ4 Human SwissProt: Q69ZK9 Mouse SwissProt: Q62888 Rat Unigene: 26229 Human Unigene: 55111 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
神经素是一类具有N-末端疏水结构域、一个大的酯酶同源结构域、一个跨膜区、一个短胞质结构域和一个EF手结合结构域（1,2）的质膜蛋白家族。神经素家族的成员包括神经球蛋白1、神经球蛋白2和神经球蛋白3。神经兴奋素在兴奋性神经元突触裂中表达。神经素与中枢神经细胞表面蛋白B-Nexxin结合，在中枢神经系统突触的形成和重塑中发挥作用。神经调节素1B结合神经纤维蛋白1的EF手部结构域，需要钙离子。神经素也与PSD-95结合，它可以招募突触的离子通道和神经递质受体。