分子量:21.6 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human EMMPRIN, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human EMMPRIN, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 21.6 kDa. The predicted N-terminus is Ala 22. The reducing (R) protein migrates as 26-33 kDa in SDS-PAGE  due to glycosylation.

产品背景:CD147, also known as Basigin (BSG), or extracellular matrix metalloproteinase inducer (EMMPRIN). The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.