Diazepam Binding Inhibitor,乙酰辅酶A结合蛋白抗体

产品编号HZ-11658R
英文名称Diazepam Binding Inhibitor
中文名称乙酰辅酶A结合蛋白抗体
别 名ACBD; ACBD 1; ACBD1; ACBP; ACBP_HUMAN; Acyl CoA binding domain containing 1; Acyl CoA binding protein; Acyl Coenzyme A binding domain containing 1; acyl coenzyme A binding protein; Acyl-CoA-binding protein; acyl-Coenzyme A binding domain containing 1; CCK RP; CCKRP; Cholecystokinin releasing peptide trypsin sensitive; DBI; Diazepam-binding inhibitor; endozepine; EP; GABA receptor modulator acyl Coenzyme A binding protein; GABA receptor modulator.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 Alzheimer's
抗体来源Rabbit
克隆类型Polyclonal
Diazepam Binding Inhibitor,乙酰辅酶A结合蛋白抗体交叉反应Human, Mouse, Rat, Pig, Cow, Sheep,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ACBD/Diazepam Binding Inhibitor (61-87aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Diazepam Binding Inhibitor,乙酰辅酶A结合蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Subunit:
Monomer.

Subcellular Location:
Endoplasmic reticulum. Golgi apparatus.Note=Golgi localization is dependent on ligand binding.

Tissue Specificity:
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.

Similarity:
Belongs to the ACBP family.
Contains 1 ACB (acyl-CoA-binding) domain.

Diazepam Binding Inhibitor,乙酰辅酶A结合蛋白抗体Database links:
Entrez Gene: 1622 Human
Omim: 125950 Human
SwissProt: P07108 Human
Unigene: 78888 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.