BRN3B,脑特定蛋白Brn3B抗体

产品编号HZ-6985R
英文名称BRN3B
中文名称脑特定蛋白Brn3B抗体
别 名BRN3B; class 4; transcription factor 2; Brain specific homeobox/POU domain protein 3B; Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3B; BRN3.2; Brn3b POU domain transcription factor; PO4F2_HUMAN; POU class 4 homeobox 2; POU domain; POU domain class 4 transcription factor 2; POU domain protein; POU4F2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 干细胞 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
BRN3B,脑特定蛋白Brn3B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BRN3B/POU4F2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BRN3B,脑特定蛋白Brn3B抗体PubMedPubMed
产品介绍background:
The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU (Pit-Oct-Unc) domain proteins, whereas Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor. Interestingly, Brn-3a has two functional transactivating domains, one at the amino-terminus and one at the carboxy-terminus. Brn-2 is thought to be involved in smooth muscle cell development and differentiation.

Function:
Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular Location:
Nucleus speckle.

Tissue Specificity:
Brain. Seems to be specific to the retina.

Post-translational modifications:

Similarity:
Belongs to the POU transcription factor family. Class-4 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.

BRN3B,脑特定蛋白Brn3B抗体Database links:
UniProtKB/Swiss-Prot: Q12837.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.