ADRM1抗体
Applications
| In-house applications |
ELISA, IHC, IF, IP, FC, WB Application not tested? Please see our Guarantee. |
| Published applications |
IHC, WB |
Publications |
5 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human, mouse |
|
Images
Prev12Next
 HEK-293 cells were subjected to SDS PAGE followed by western blot with 11468-1-AP(ADRM1 antibody) at dilution of 1:1000 Immunohistochemical of paraffin-embedded human colon cancer using 11468-1-AP(ADRM1 antibody) at dilution of 1:100 (under 40x lens) Immunofluorescent analysis of MCF-7 cells, using ADRM1 antibody 11468-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye). 1X10^6 MCF-7 cells were stained with 0.2ug ADRM1 antibody (11468-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000. IP Result of anti-ADRM1 (IP:11468-1-AP, 3ug; Detection:11468-1-AP 1:500) with mouse testis tissue lysate 8000ug.
|
| Positive WB detected in |
HEK-293 cells, HeLa cells, mouse ovary tissue, mouse testis tissue |
| Positive IP detected in |
Mouse testis tissue |
| Positive IHC detected in |
Human colon cancer tissue |
| Positive IF detected in |
MCF-7 cells |
| Positive FC detected in |
MCF-7 cells |
| Recommended dilution |
WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200 |
ADRM1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
ADRM1 fusion protein ag1997 |
Full name |
Adhesion regulating molecule 1 |
Calculated molecular
weight |
407aa,42 kDa |
Observed molecular
weight |
46kd |
GenBank accession
number |
BC017245 |
Gene ID (NCBI) |
11047 |
| Gene symbol |
ADRM1 |
Synonyms |
Adhesion regulating molecule 1, ADRM1, ARM 1, ARM1, GP110, hRpn13, Rpn13, Rpn13 homolog |
Background ADRM1抗体
|
The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts. ADRM1抗体
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