MAPK8/MAPK9 polyclonal antibody
产品名称: MAPK8/MAPK9 polyclonal antibody
英文名称: MAPK8/MAPK9 polyclonal antibody
产品编号: PAB19484
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAPK8/MAPK9.
- Immunogen:
- A synthetic peptide corresponding to amino acids 344-363 at middle region of human MAPK8 and MAPK9.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- It identical to the related mouse and rat sequence.
- Form:
- Lyophilized
- Purification:
- Immunoaffinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
Immunocytochemistry (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
- Western Blot
- Western blot analysis of tissue and cell extracts with MAPK8/MAPK9 polyclonal antibody (Cat # PAB19484).
Lane 1, rat brain tissue lysate.
Lane 2, rat thymus tissue lysate.
Lane 3, MCF-7 whole cell lysate.
Lane 4, HeLa whole cell lysate.
Lane 5, Jurkat whole cell lysate.
Lane 6, MM231 whole cell lysate.
Lane 7, 6T-CEM whole cell lysate.
- Application Image
- Western Blot
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunocytochemistry
- Entrez GeneID:
- 5599
- Gene Name:
- MAPK8
- Gene Alias:
- JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1
- Gene Description:
- mitogen-activated protein kinase 8
- Omim ID:
- 601158
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- JNK1 alpha protein kinase,JNK1 beta protein kinase,JUN N-terminal kinase,OTTHUMP00000019552,OTTHUMP00000019555,OTTHUMP00000019556,OTTHUMP00000019558,c-Jun N-terminal kinase 1,mitogen-activated protein kinase 8 isoform JNK1 alpha1,mitogen-activated protein
- Entrez GeneID:
- 5601
- Gene Name:
- MAPK9
- Gene Alias:
- JNK-55,JNK2,JNK2A,JNK2ALPHA,JNK2B,JNK2BETA,PRKM9,SAPK,p54a,p54aSAPK
- Gene Description:
- mitogen-activated protein kinase 9
- Omim ID:
- 602896
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- Jun kinase,MAP kinase 9,c-Jun N-terminal kinase 2,c-Jun kinase 2,mitogen-activated protein kinase 9 isoform JNK2 alpha2,stress-activated protein kinase JNK2
- Interactome