EGFLAM,皮卡丘素抗体

产品编号HZ-11346R
英文名称EGFLAM
中文名称皮卡丘素抗体
别 名fibronectin type-III and laminin G-like domain-containing protein; Agrin-like protein; AGRINL; AGRNL; EGF-like; EGF-like, fibronectin type III and laminin G domains; EGF-like, fibronectin type-III and laminin G-like domain-containing protein; EGFLA_HUMAN; EGFLAM; FLJ39155; Pikachurin.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 细胞类型标志物 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Horse,
EGFLAM,皮卡丘素抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量109kDa
细胞定位细胞膜 细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Pikachurin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EGFLAM,皮卡丘素抗体PubMedPubMed
产品介绍background:
EGFLAM is a 1,017 amino acid secreted protein containing three EGF-like domains, two fibronectin type-III domains, and three laminin G-like domains. Colocalizing with bassoon, CtBP and dystroglycan in photoreceptor synaptic terminals, EGFLAM is involved in retinal photoreceptor ribbon synapse formation. EGFLAM may also promote matrix assembly and cell adhesion. Existing as five alternatively spliced isoforms, the gene encoding EGFLAM maps to human chromosome 5p13.2. Chromosome 5 makes up approximately 6% of the human genome and contains 181 million base pairs, which encode 1,000 genes. Cockayne syndrome, Treacher Collins syndrome, acute myelogenous leukemias and myelodysplastic syndrome are associated with genes present on chromosome 5.

Function:
Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness.

EGFLAM,皮卡丘素抗体Subunit:
Interacts with DAG1 alpha-dystroglycan

Subcellular Location:
Secreted; extracellular space; extracellular matrix. Cell junction > synapse. Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals.

Post-translational modifications:
O-glycosylated; contains chondroitin sulfate and heparan sulfate.

Similarity:
Contains 3 EGF-like domains.
Contains 2 fibronectin type-III domains.
Contains 3 laminin G-like domains.

Database links:
Entrez Gene: 133584 Human
Entrez Gene: 268780 Mouse
Entrez Gene: 365691 Rat
Entrez Gene: 534427 Cow
SwissProt: A3KN33 Cow
SwissProt: Q63HQ2 Human
SwissProt: Q4VBE4 Mouse
SwissProt: B4F785 Rat
Unigene: 20103 Human
Unigene: 203208 Mouse
Unigene: 27713 Rat

EGFLAM,皮卡丘素抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.