SSX2,滑膜肉瘤X染色体相关2抗体

产品编号HZ-11312R
英文名称SSX2
中文名称滑膜肉瘤X染色体相关2抗体
别 名CT5.2; X breakpoint 2; Cancer/testis antigen 5.2; CT5.2; HD21; hom mel 40; HOM-MEL-40; MGC119055; Protein SSX2; RP11-552J9.2; sarcoma, synovial, X-chromosome related 2; SSx; SSX2; SSX2-SYT fusion gene, included; SSX2_HUMAN; SSX2B; Synovial sarcoma; synovial sarcoma X breakpoint 2; Tumor antigen HOM-MEL-40.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
SSX2,滑膜肉瘤X染色体相关2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SSX2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SSX2,滑膜肉瘤X染色体相关2抗体PubMedPubMed
产品介绍background:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

Function:
Could act as a modulator of transcription.

Subunit:
Interacts via its N-terminal region with RAB3IP and SSX2IP.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.

SSX2,滑膜肉瘤X染色体相关2抗体DISEASE:
Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Similarity:
Belongs to the SSX family.
Contains 1 KRAB-related domain.

Database links:
Entrez Gene: 6757 Human
Entrez Gene: 727837 Human
Omim: 300192 Human
SwissProt: Q16385 Human
Unigene: 289105 Human
Unigene: 661107 Human

SSX2,滑膜肉瘤X染色体相关2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.