分子量:57.8 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Siglec-2 (176-687), His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human Siglec-2 (176-687), His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 57.8 kDa. The predicted N-terminus is Trp 176. The reducing (R) protein migrates as 90-100 kDa in SDS-PAGE  due to glycosylation.

产品背景:B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.