BHLHB5,螺旋一环一螺旋蛋白5抗体

产品编号HZ-11808R
英文名称BHLHB5
中文名称螺旋一环一螺旋蛋白5抗体
别 名BETA 3; Basic helix loop helix protein 5; Beta3; BHE22_HUMAN; bHLHB5; bHLHe22; CAGL85; Class B basic helix-loop-helix protein 5; Class E basic helix-loop-helix protein 22; Class II bHLH protein BHLHB5; TNRC20; Trinucleotide repeat containing 20; Trinucleotide repeat-containing gene 20 protein.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
BHLHB5,螺旋一环一螺旋蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BHLHB5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BHLHB5,螺旋一环一螺旋蛋白5抗体PubMedPubMed
产品介绍background:
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes. Class A proteins include the ubiquitously expressed E-box binding factors E12/E47, ITF2 and HEB (BETA 1 or HTF4). Class B proteins such as Myo D, myogenin and Neuro D (BETA 2) are transiently expressed and exhibit a more limited tissue distribution. Class A proteins heterodimerize with class B proteins to activate transcription. Working in opposition to these positively acting factors are a specialized group of proteins that function as dominant negative regulators. For instance, the Id family of transcriptional repressors contains a HLH region required for dimerization but lacks a functional DNA-binding domain. The Id family can therefore form heterodimers with the myogenic family, but the resulting complexes are transcriptionally inactive. BETA 3 is a protein that is functionally similar to members of the Id family in that it can inhibit the binding of E47 homodimers as well as E47/Neuro D and E47/Myo D heterodimers to consensus DNA sequences . In contrast to members of the Id family, BETA 3 contains a putative DNA-binding domain.

Function:
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA.

Subunit:

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain-specific, with the highest expression in the cerebellum.

BHLHB5,螺旋一环一螺旋蛋白5抗体Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:
Entrez Gene: 27319 Human
Entrez Gene: 59058 Mouse
Entrez Gene: 365748 Rat
Omim: 613483 Human
SwissProt: Q8NFJ8 Human
SwissProt: Q8C6A8 Mouse
Unigene: 388788 Human
Unigene: 591870 Human
Unigene: 149938 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.