FITC标记的L3MBTL3蛋白抗体
产品名称： FITC标记的L3MBTL3蛋白抗体
英文名称： Anti-L3MBTL3/FITC
产品编号： HZ-12342R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-L3MBTL3/FITC Conjugated antibody
FITC标记的L3MBTL3蛋白抗体
| 英文名称 | Anti-L3MBTL3/FITC |
| 中文名称 | FITC标记的L3MBTL3蛋白抗体 |
| 别 名 | Hl(3)mbt like protein; KIAA1798; l(3)mbt like 3 (Drosophila); l(3)mbt like 3; L(3)mbt like 3 protein; Lethal(3)malignant brain tumor like 3 protein; MBT1; LMBL3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 干细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human L3MBTL3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Polycomb group (PcG) proteins are important for maintaining the transcriptionally repressed state of target genes and are thought to function via chromatin modification. PcG proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. PcG proteins are also required for normal maturation of myeloid progenitor cells. A putative PcG protein, L3MBTL3 (lethal(3)malignant brain tumor-like protein 3), also known as MBT-1 or KIAA1798, is a 780 amino acid protein containing three MBT repeats and one SAM (sterile alpha motif) domain. Localized to the nucleus, L3MBTL3 interacts with RING1B, another PcG protein that may be involved in the specification of anterior-posterior axis and cell proliferation in early development. L3MBTL3 exists as two isoforms produced by alternative splicing events. Function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells. Subunit: Interacts with RNF2 (By similarity). Subcellular Location: Nuclear. Similarity: Contains 3 MBT repeats. Contains 1 SAM (sterile alpha motif) domain. Database links: UniProtKB/Swiss-Prot: Q96JM7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
多梳群（polycomb group，PcG）蛋白对于维持靶基因的转录抑制状态很重要，并且被认为通过染色质修饰起作用。PcG蛋白组装成多聚体蛋白复合物，在连续的细胞世代中维持基因的转录抑制状态。PCG蛋白也是髓系祖细胞正常成熟所必需的。一种推测的PcG蛋白，L3MBTL3（致死性（3）恶性脑肿瘤样蛋白3），也称为MBT-1或KIAA1798，是一种780氨基酸蛋白，含有3个MBT重复序列和一个SAM（无菌α基序）结构域。L3MBTL3定位于细胞核，与RING1B相互作用，RING1B是另一种PcG蛋白，在早期发育中可能参与前后轴和细胞增殖的规范。L3MbTL3存在于由选择性剪接事件产生的两种异构体中。