分子量:22.2 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Mouse Fc gamma RIIB / CD32b, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Mouse Fc gamma RIIB / CD32b, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 22.2 kDa. The predicted N-terminus is Thr 40. The reducing (R) protein migrates as 35-40 kDa in SDS-PAGE  due to glycosylation.

产品背景:Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. 
There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.