FITC标记的转化生长因子β1结合蛋白抗体
产品名称： FITC标记的转化生长因子β1结合蛋白抗体
英文名称： Anti-CD109/FITC
产品编号： HZ-6067R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-CD109/FITC Conjugated antibody
FITC标记的转化生长因子β1结合蛋白抗体
| 英文名称 | Anti-CD109/FITC |
| 中文名称 | FITC标记的转化生长因子β1结合蛋白抗体 |
| 别 名 | p180; 8A3; 150 KDa TGF beta 1 binding protein; 7D1; DKFZp762L1111; E123; Platelet specific Gov antigen; r150; RP11 525G3.1; Activated T cell marker CD109; CD 109 antibody CD109 antigen; CPAMD7; FLJ38569; FLJ41966; Gov system alloantigens on platelets. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 细胞表面分子 糖蛋白 淋巴细胞 t-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 154kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD109 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CD109 is a a novel member of the alpha2-macroglobulin (alpha2M)/complement superfamily. It is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein of approximately 170 kd found on endothelial cells, activated platelets and T-cells and on a subset of hematopoietic stem and progenitor cells. Although it has been suggested that T-cell CD109 may play a role in antibody-inducing T-helper function and it is known that platelet CD109 carries the Gov alloantigen system, the role of CD109 in hematopoietic cells remains largely unknown. CD109 has been identified as part of the TGF-beta receptor system in human keratinocytes and upregulation of CD109 expression has been observed in several different types of tumour. Function: Modulates negatively TGFB1 signaling in keratinocytes. Subunit: Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. Post-translational modifications: N-glycosylated. 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Database links: Entrez Gene: 135228 Human Entrez Gene: 235505 Mouse Entrez Gene: 363104 Rat Omim: 608859 Human SwissProt: Q6YHK3 Human SwissProt: Q8R422 Mouse Unigene: 399891 Human Unigene: 32955 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 姬：8个糖基化位点；2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. |
CD109是阿尔法2巨球蛋白（AlpHA2m）/补体超家族的新成员。它是一种糖基磷脂酰肌醇（GPI）连接的细胞表面糖蛋白，约170 kD存在于内皮细胞、活化血小板和T细胞上，以及在造血干细胞和祖细胞的一个子集上。虽然已经提出，T细胞CD109可能在抗体诱导的T辅助功能中起作用，并且已知血小板CD109携带GOV同种抗原系统，但CD109在造血细胞中的作用仍然是未知的。CD109已被鉴定为人角质形成细胞中TGF-β受体系统的一部分，在几种不同类型的肿瘤中已观察到CD109表达上调。