分子量:71.7 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human ErbB3, Strep Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human ErbB3, Strep Tag is fused with twin strep tag at the C-terminus, and has a calculated MW of 71.7 kDa. The predicted N-terminus is Ser 20. The reducing (R) protein migrates as 100-110 kDa in SDS-PAGE  due to glycosylation.

产品背景:ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.